A change in hippocampal protocadherin gamma expression in the learned helpless rat

Garafola, Craig S., Henn, Fritz A. (October 2014) A change in hippocampal protocadherin gamma expression in the learned helpless rat. Brain Research, 1593. pp. 55-64. ISSN 0006-8993

URL: http://www.ncbi.nlm.nih.gov/pubmed/25446008
DOI: 10.1016/j.brainres.2014.08.071


Depression is a disease with a complex etiology, that is only beginning to be studied from a genetic perspective. A selectively bred line of rats susceptible to learned helplessness, a model of depression, presents an opportunity to search for genes affecting the depressive symptoms found in the helpless model which may provide clues toward understanding the human disease. A microarray study revealed a small set of genes with altered expression in the hippocampus of the congenitally helpless rats. We selected one of these genes, a member of the γ-protocadherins for further study to determine the basis for the change in expression. Helpless animals demonstrated an increased expression primarily in CA1 neurons. Protocadherins have been implicated in synapse development and these results suggest they may play a role related to the reduced neuroplasticity observed in depression. Additionally, a number of genes linked to pathways known or suspected to be involved in depression were also detected, these will require further verification and study.

Item Type: Paper
Uncontrolled Keywords: Learned helplessness Depression hippocampus Protocadherin
Subjects: diseases & disorders > mental disorders > mood disorders > depression
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 14 October 2014
Date Deposited: 24 Oct 2014 15:10
Last Modified: 05 Dec 2014 21:05
Related URLs:
URI: https://repository.cshl.edu/id/eprint/30872

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving