Huang, Z. J. (September 2014) Toward a Genetic Dissection of Cortical Circuits in the Mouse. Neuron, 83 (6). pp. 1284-1302. ISSN 0896-6273
Abstract
The mammalian neocortex gives rise to a wide range of mental activities and consists of a constellation of interconnected areas that are built from a set of basic circuit templates. Major obstacles to understanding cortical architecture include the diversity of cell types, their highly recurrent local and global connectivity, dynamic circuit operations, and a convoluted developmental assembly process rooted in the genome. With our increasing knowledge of gene expression and developmental genetic principles, it is now feasible to launch a program of genetic dissection of cortical circuits through systematic targeting of cell types and fate mapping of neural progenitors. Strategic design of even a modest number of mouse driver lines will facilitate efforts to compile a cell type parts list, build a Cortical Cell Atlas, establish experimental access to modern tools, integrate studies across levels, and provide coordinates for tracing developmental trajectory from circuit assembly to functional operation.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits Investigative techniques and equipment > Whole Brain Circuit Mapping |
| CSHL Authors: | |
| Communities: | CSHL labs > Huang lab |
| Depositing User: | Matt Covey |
| Date: | 17 September 2014 |
| Date Deposited: | 25 Sep 2014 14:21 |
| Last Modified: | 25 Sep 2014 14:21 |
| PMCID: | PMC4169123 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30818 |
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