Insulin receptor signaling in the development of neuronal structure and function

Chiu, S. L., Cline, H. T. (2010) Insulin receptor signaling in the development of neuronal structure and function. Neural Dev, 5. p. 7. ISSN 1749-8104

DOI: 10.1186/1749-8104-5-7


Sensory experience plays a crucial role in regulating neuronal shape and in developing synaptic contacts during brain formation. These features are required for a neuron to receive, integrate, and transmit signals within the neuronal network so that animals can adapt to the constant changing environment. Insulin receptor signaling, which has been extensively studied in peripheral organ systems such as liver, muscle and adipocyte, has recently been shown to play important roles in the central nervous system. Here we review the current understanding of the underlying mechanisms that regulate structural and functional aspects of circuit development, particularly with respect to the role of insulin receptor signaling in synaptic function and the development of dendritic arbor morphology. The potential link between insulin receptor signaling malfunction and neurological disorders will also be discussed.

Item Type: Paper
Uncontrolled Keywords: Animals Dendrites/physiology Neural Pathways/*anatomy & histology/*growth & development Neurons/*cytology/*physiology Receptor, Insulin/*physiology *Signal Transduction Synapses/physiology
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > insulin receptor
CSHL Authors:
Communities: CSHL labs > Cline lab
School of Biological Sciences > Publications
Depositing User: Matt Covey
Date: 2010
Date Deposited: 22 Sep 2014 19:11
Last Modified: 26 Sep 2014 18:51
PMCID: PMC2843688
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