Chapman, P. F., Frenguelli, B. G., Smith, A., Chen, C. M., Silva, A. J. (March 1995) The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity. Neuron, 14 (3). pp. 591-7. ISSN 0896-6273 (Print)
Abstract
The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this kinase also has a crucial role in presynaptic plasticity. Paired-pulse facilitation is blunted in the CA1 region of mice heterozygous for a targeted mutation of alpha CaMKII, confirming that this kinase can promote neurotransmitter release. Unexpectedly, field and whole-cell recordings of posttetanic potentiation show that the synaptic responses of mutants are larger than those of controls, indicating that alpha CaMKII can also inhibit transmitter release immediately after tetanic stimulation. Thus, alpha CaMKII has the capacity either to potentiate or to depress excitatory synaptic transmission depending on the pattern of presynaptic activation.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Ca(2+)-Calmodulin Dependent Protein Kinase/genetics/ metabolism Crosses, Genetic Electric Stimulation Evoked Potentials Heterozygote Hippocampus/ physiology In Vitro Long-Term Potentiation Mice Mice, Inbred C57BL Mice, Neurologic Mutants Mutation Neuronal Plasticity Patch-Clamp Techniques Pyramidal Cells/ physiology Research Support, Non-U.S. Gov't Synapses/ physiology Time Factors |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation organism description > animal organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal > mammal > rodent > mouse bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Jessica Koos |
| Date: | March 1995 |
| Date Deposited: | 15 Aug 2014 19:18 |
| Last Modified: | 15 Aug 2014 19:18 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30572 |
Actions (login required)
 |
Administrator's edit/view item |