Computational methods for DNA copy-number analysis of tumors

Kendall, J., Krasnitz, A. (July 2014) Computational methods for DNA copy-number analysis of tumors. Methods in Molecular Biology, 1176. pp. 243-59. ISSN 1940-6029 (Electronic)1064-3745 (Linking)

DOI: 10.1007/978-1-4939-0992-6_20


Study of DNA copy-number variation is a key part of cancer genomics. With the help of a comprehensive multistep computational procedure described here, copy-number profiles of tumor tissues or individual tumor cells may be generated and interpreted, starting with data acquired by next-generation sequencing. Several of the methods presented are specifically designed to handle cancer-related copy-number profiles. These include accounting for variation of ploidy and distilling somatic copy number alterations from the inherited background.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > computational biology
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > copy number variants
CSHL Authors:
Communities: CSHL labs > Krasnitz lab
CSHL labs > Wigler lab
CSHL Cancer Center Program > Cancer Genetics
Depositing User: Matt Covey
Date: 20 July 2014
Date Deposited: 25 Jul 2014 14:40
Last Modified: 26 Jan 2017 20:25
PMCID: PMC5136461
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