Single cell sequencing approaches for complex biological systems

Baslan, T., Hicks, J. (July 2014) Single cell sequencing approaches for complex biological systems. Curr Opin Genet Dev, 26c. pp. 59-65. ISSN 0959-437x

DOI: 10.1016/j.gde.2014.06.004


Biological phenotype is the output of complex interactions between heterogeneous cells within a specified niche. These interactions are tightly governed and regulated by the genetic, epigenetic, and transcriptional states of single cells, with deregulation of these states resulting in disease. As such, genome wide single cell investigations are bound to enhance our knowledge of the underlying principles that govern biological systems. Recent technological advances have enabled such investigations in the form of single-cell sequencing. Here, we review the most recent developments in genome wide profiling of single cells, discuss some of the novel biological observations gleaned by such investigations, and touch upon the promise of single cell sequencing in unraveling biological systems.

Item Type: Paper
Subjects: Investigative techniques and equipment > assays > next generation sequencing
Investigative techniques and equipment > assays > Single cell sequencing
CSHL Authors:
Communities: CSHL labs > Hicks lab
Depositing User: Matt Covey
Date: 10 July 2014
Date Deposited: 18 Jul 2014 15:04
Last Modified: 18 Jul 2014 15:04
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