Moss, D. W., Whitaker, K. B., Parmar, C., Heckmatt, J., Wikowski, J., Sewry, C., Dubowitz, V. (October 1981) Activity of creatine kinase in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, determined by the "European" recommended method with NAC-EDTA activation. Clinica chimica acta; international journal of clinical chemistry, 116 (2). pp. 209-16. ISSN 0009-8981 (Print)0009-8981
Abstract
Creatine kinase activity has been measured at 37 degrees C in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, with activation by N-acetyl cysteine (NAC) and EDTA as recommended by several European committees on standardisation. The upper limit of the reference range for healty women was found to be 170 U/l. The distributions of creatine kinase activities in healthy and carrier women have been used to calculate probability of carrier status as a function of creatine kinase activity. Although the range of creatine kinase activities in normal cord blood is wide, the data provide a basis for interpretation when Duchenne muscular dystrophy is suspected.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Acetylcysteine/*pharmacology Adolescent Adult Creatine Kinase/*blood/genetics Edetic Acid/*pharmacology Female Fetal Blood/*enzymology Heterozygote Detection Humans Kinetics Middle Aged Muscular Dystrophies/*enzymology/genetics Pregnancy Reference Values |
| Subjects: | diseases & disorders > congenital hereditary genetic diseases > muscular dystrophy |
| CSHL Authors: | |
| Communities: | Banbury Center |
| Depositing User: | Matt Covey |
| Date: | 26 October 1981 |
| Date Deposited: | 26 Nov 2014 19:24 |
| Last Modified: | 26 Nov 2014 19:24 |
| URI: | https://repository.cshl.edu/id/eprint/30422 |
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