Jones, G. E., Witkowski, J. A. (April 1981) Analysis of skin fibroblast aggregation in Duchenne muscular dystrophy. Journal of cell science, 48. pp. 291-300. ISSN 0021-9533 (Print)0021-9533
Abstract
Skin fibroblasts from patients with Duchenne muscular dystrophy have a low intercellular adhesiveness compared with normal cells when aggregated in a Couette viscometer (collision efficiencies of 2.52 and 4.62, respectively). The pattern of aggregation was quantitated using a digitizer system to measure the areas of particles (single cells and aggregates) formed after 20 min aggregation. This size analysis showed that the majority of dystrophic cells remained unaggregated but that a small number of very large aggregates was always formed. Normal cell suspensions only rarely contained large aggregates but contained many intermediate-size aggregates. These differences in intercellular adhesiveness and aggregate pattern formation indicate that there may be an alteration in the surface of dystrophic cells.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Cell Adhesion Cell Aggregation Cells, Cultured Child Child, Preschool Fibroblasts/pathology Humans Infant Muscular Dystrophies/*pathology Skin/*pathology |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts diseases & disorders > congenital hereditary genetic diseases > muscular dystrophy |
| CSHL Authors: | |
| Communities: | Banbury Center |
| Depositing User: | Matt Covey |
| Date: | April 1981 |
| Date Deposited: | 26 Nov 2014 17:00 |
| Last Modified: | 26 Nov 2014 17:00 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30418 |
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