Kojima, Y., Tam, O. H., Tam, P. P. (June 2014) Timing of developmental events in the early mouse embryo. Seminars in Cell & Developmental Biology, 34. pp. 65-75. ISSN 1084-9521
Abstract
The timing of developmental events during early mouse development has been investigated in embryos that have been subject to experimental manipulation of cell number and tissue mass. These phenomenological studies revealed that the timing of preimplantation events, such as compaction, formation of blastocyst cavity and lineage allocation is correlated with the rounds of cleavage division or DNA replication of the blastomeres. Timing of postimplantation processes, such as formation of proamniotic cavity and onset of gastrulation is sensitive to cell number and probably the tissue mass, which may be measured by a mechanosensory signaling mechanism. Developmental changes in these two physical attributes are correlated with the cell proliferative activity and the growth trajectory of the whole embryo prior to the transit to organogenesis. During organogenesis, timing of morphogenesis appears to be regulated by individual devices that could be uncoupled during compensatory growth. Insights of the timing mechanism may be gleaned from the analysis of genomic activity associated with the transition through developmental milestones.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal organism description > animal > developmental stage organism description > animal > developmental stage > embryo organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs > Hammell M. lab |
| Depositing User: | Matt Covey |
| Date: | 17 June 2014 |
| Date Deposited: | 27 Jun 2014 15:57 |
| Last Modified: | 24 Oct 2014 16:32 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30349 |
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