Imposing specificity by localization: mechanism and evolvability

Ptashne, M., Gann, A. (November 1998) Imposing specificity by localization: mechanism and evolvability. Current Biology, 8 (22). R812-22. ISSN 0960-9822

DOI: 10.1016/S0960-9822(07)00508-8


Cells detect extracellular signals by allostery and then give those signals meaning by 'regulated localization'. We suggest that this formulation applies to many biological processes and is particularly well illustrated by the mechanisms of gene regulation. Analysis of these mechanisms reveals that regulated localization requires simple molecular interactions that are readily used combinatorially. This system of regulation is highly 'evolvable', and its use accounts, at least in part, for the nature of the complexities observed in biological systems.

Item Type: Paper
Uncontrolled Keywords: Animals DNA-Binding Proteins/metabolism *Gene Expression Regulation Gene Expression Regulation, Bacterial Humans *Signal Transduction Trans-Activators/metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
CSHL Authors:
Communities: School of Biological Sciences > SBS Administration
Depositing User: Matt Covey
Date: 5 November 1998
Date Deposited: 23 Jun 2014 19:36
Last Modified: 09 Sep 2021 18:45
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