Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI

Northoff, G., Braus, D. F., Sartorius, A., Khoram-Sefat, D., Russ, M., Eckert, J., Herrig, M., Leschinger, A., Bogerts, B., Henn, F. A. (July 1999) Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI. Psychological Medicine, 29 (4). pp. 997-1002. ISSN 0033-2917 (Print)0033-2917 (Linking)



BACKGROUND: Catatonia, a symptom complex with motor, affective and cognitive symptoms seen in a variety of psychotic conditions and with organic disease, was examined using a motor task using functional magnetic resonance imaging (fMRI). METHODS: Two acute catatonic patients and two age- and sex-matched healthy controls performed sequential finger opposition (SFO) after being medicated with 2 mg of lorazepam (i.v.). Functional magnetic resonance images were collected using a gradient echo pulse sequence (EPI). RESULTS: Patients with catatonia showed reduced motor activation of the contralateral motor cortex during SFO of the right hand, ipsilateral activation was similar for patients and controls. There were no differences in the activation of the SMA. During left hand activation the right-handed catatonic patients showed more activation in the ipsilateral cortex, a reversal from the normal pattern of activation in which the contralateral side shows four to five times more activation than the ipsilateral side. CONCLUSIONS: In catatonic patients there is a decreased activation in motor cortex during a motor task compared to matched medicated healthy controls. In addition activation of the non-dominant side, left-handed activity in right-handed patients, results in a total reversal of the normal pattern of lateral activation suggesting a disturbance in hemispheric localization of activity during a catatonic state.

Item Type: Paper
Uncontrolled Keywords: Acute Disease Adult Arousal/drug effects/*physiology Brain Mapping Dominance, Cerebral/drug effects/*physiology Female Humans Injections, Intravenous Lorazepam/therapeutic use *Magnetic Resonance Imaging Male Motor Cortex/drug effects/*physiopathology Motor Skills/drug effects/*physiology Schizophrenia, Catatonic/drug therapy/*physiopathology
Subjects: Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: July 1999
Date Deposited: 06 Jun 2014 20:52
Last Modified: 06 Jun 2014 20:52

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