Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study

Guenther, W., Brodie, J. D., Bartlett, E. J., Dewey, S. L., Henn, F. A., Volkow, N. D., Alper, K., Wolkin, A., Cancro, R., Wolf, A. P. (1994) Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study. European Archives of Psychiatry and Clinical Neuroscience, 244 (3). pp. 115-25. ISSN 0940-1334 (Print)0940-1334 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7803524
DOI: 10.1007/BF02191884


Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.

Item Type: Paper
Uncontrolled Keywords: Adult Arousal/physiology Attention/*physiology Blood Glucose/*metabolism Brain/*radionuclide imaging Brain Mapping Cerebral Cortex/radionuclide imaging Deoxyglucose/metabolism Energy Metabolism/*physiology Humans Male Mental Recall/physiology Middle Aged Motor Skills/*physiology Schizophrenia/*radionuclide imaging Serial Learning/physiology *Tomography, Emission-Computed
Subjects: diseases & disorders > mental disorders > schizophrenia
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 1994
Date Deposited: 06 Jun 2014 20:37
Last Modified: 06 Jun 2014 20:37
Related URLs:
URI: https://repository.cshl.edu/id/eprint/30246

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