Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats

Lachman, H. M., Papolos, D. F., Weiner, E. D., Ramazankhana, R., Hartnick, C., Edwards, E., Henn, F. A. (June 1992) Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats. Molecular Brain Research, 14 (1-2). pp. 94-100. ISSN 0169-328X

URL: http://www.ncbi.nlm.nih.gov/pubmed/1353857
DOI: 10.1016/0169-328X(92)90015-4


The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is involved in the regulation of a number of behaviors known to be altered in clinical depression as well as in learned helplessness, we measured the relative level of NPY mRNA in the hippocampus and cortex of control Sprague Dawley (SD), LH and NLH rats. We find that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats. By contrast, cortical NPY mRNA and hippocampal pre-proenkephalin and somatostatin mRNA levels were not significantly different in the 3 strains. The data suggest that the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH rats to develop learned helplessness.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Isomerases/biosynthesis Animals Association Learning Carrier Proteins/biosynthesis Cerebral Cortex/metabolism Disease Susceptibility/metabolism Enkephalins/biosynthesis Escape Reaction Gene Expression Genetic Predisposition to Disease *Helplessness, Learned Hippocampus/*metabolism Malate Dehydrogenase/biosynthesis Male Neuropeptide Y/*biosynthesis/genetics/physiology Peptidylprolyl Isomerase Protein Precursors/biosynthesis RNA, Messenger/analysis Rats Rats, Inbred Strains/*genetics/psychology Somatostatin/biosynthesis
Subjects: diseases & disorders > mental disorders > mood disorders > depression
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: June 1992
Date Deposited: 06 Jun 2014 20:13
Last Modified: 06 Jun 2014 20:13
Related URLs:
URI: https://repository.cshl.edu/id/eprint/30242

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