5-HT1b receptors in an animal model of depression

Edwards, E., Harkins, K., Wright, G., Henn, F. A. (January 1991) 5-HT1b receptors in an animal model of depression. Neuropharmacology, 30 (1). pp. 101-5. ISSN 0028-3908 (Print)0028-3908

URL: http://www.ncbi.nlm.nih.gov/pubmed/2046876
DOI: 10.1016/0028-3908(91)90050-L


After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HT receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT1b receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT1b receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbic-hypothalamic circuit serving as a center for adaptation to stress.

Item Type: Paper
Uncontrolled Keywords: Animals Brain/*metabolism Cerebral Cortex/metabolism Depression/metabolism/*physiopathology Disease Models, Animal Electroshock Escape Reaction *Helplessness, Learned Hippocampus/metabolism Hypothalamus/metabolism Kinetics Male Rats Rats, Inbred Strains Receptors, Serotonin/*metabolism Reference Values
Subjects: organism description > animal
diseases & disorders > mental disorders > mood disorders > depression
organism description > model organism
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neurotransmitter
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein receptor
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: January 1991
Date Deposited: 09 Jul 2014 14:45
Last Modified: 09 Jul 2014 14:45
Related URLs:
URI: https://repository.cshl.edu/id/eprint/30239

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