Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study

DeLisi, L. E., Hoff, A. L., Schwartz, J. E., Shields, G. W., Halthore, S. N., Gupta, S. M., Henn, F. A., Anand, A. K. (January 1991) Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological Psychiatry, 29 (2). pp. 159-75. ISSN 0006-3223

DOI: 10.1016/0006-3223(91)90044-M


Brain morphology was examined using magnetic resonance imaging in 30 first-episode patients with a schizophreniclike psychosis, 15 chronic schizophrenics, and 20 neurological controls. Statistical analyses of computer-generated measurements of regions of interest were controlled for gender, age, social class, and total brain volume. Lateral ventricular size was increased in both first-episode and chronic schizophrenic patients, with greater significance on the left than on the right side. Only the chronic patients, however, had reduced temporal lobe size, which also was greater on the left side. No major correlations of regional brain morphological measurements with cognitive functioning were found, although some measurements of verbal memory were correlated with parahippocampal size. This is a report of a preliminary study that suggests that some morphological brain changes may be present at the time of first treatment for a psychotic illness, whereas others may occur later in the course of illness. Future prospective studies may determine the clinical significance of these changes and whether they progress with the development of illness chronicity.

Item Type: Paper
Uncontrolled Keywords: Adolescent Adult Age Factors Brain/*anatomy & histology Cerebral Ventricles/anatomy & histology Child Chronic Disease Female Functional Laterality Humans *Magnetic Resonance Imaging Male Neuropsychological Tests Psychiatric Status Rating Scales Psychotic Disorders/diagnosis Schizophrenia/*diagnosis
Subjects: diseases & disorders > mental disorders > schizophrenia
organs, tissues, organelles, cell types and functions > organs types and functions > brain
Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 15 January 1991
Date Deposited: 24 Jun 2014 16:47
Last Modified: 24 Jun 2014 16:47
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