Neurochemical and behavioral consequences of mild, uncontrollable shock: effects of PCPA

Edwards, E., Johnson, J., Anderson, D., Turano, P., Henn, F. A. (August 1986) Neurochemical and behavioral consequences of mild, uncontrollable shock: effects of PCPA. Pharmacol Biochem Behav, 25 (2). pp. 415-21. ISSN 0091-3057 (Print)0091-3057

DOI: 10.1016/0091-3057(86)90018-3


The present experiments examined the role of the serotonergic system in the behavioral deficit produced by uncontrollable shock. In Experiment 1: Establishment of model, the behavioral potential of the Sprague-Dawley rat was defined. When exposed to mild uncontrollable stress such as a 0.8 mA electric footshock, a significant percentage of rats developed a shock escape deficit which was evident when subsequently placed in a shock escape paradigm. Serotonin depletion was produced by chronic treatment with p-chlorophenylalanine. Biogenic amine levels and 5-HT levels were monitored in various brain areas using HPLC. Following chronic treatment with PCPA, the shock escape capability of the Sprague-Dawley rat was assessed. The severe depletion of 5-HT in various brain regions was highly correlated with a dramatic improvement in the shock escape scores. Thus, the detrimental effects of exposure to a mild course of inescapable shock can be prevented by chronic treatment with PCPA. These experiments implicate the serotonergic system as a possible mediator of the "learned helplessness" phenomenon.

Item Type: Paper
Uncontrolled Keywords: Animals Biogenic Amines/analysis Brain/*physiology Brain Chemistry/drug effects Electroshock Fenclonine/*pharmacology *Helplessness, Learned Motor Activity/drug effects Rats Rats, Inbred Strains Serotonin/analysis/*physiology
Subjects: organism description > animal
diseases & disorders > mental disorders > mood disorders > depression
organism description > model organism
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: August 1986
Date Deposited: 24 Jun 2014 15:51
Last Modified: 24 Jun 2014 15:51
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