Henn, F. A., Haljamae, H., Hamberger, A. (August 1972) Glial cell function: active control of extracellular K + concentration. Brain Research, 43 (2). pp. 437-43. ISSN 0006-8993 (Print)0006-8993 (Linking)
Abstract
To investigate the ability of the glial cell to control the extracellular K+ ion concentration in the CNS 3 kinds of experiment were carried out. (1) The ability of isolated cell fractions enriched in glia or neurons to reaccumulate K+ was measured. (2) The activation of the Na+single bondK+-ATPase by K+ was measured on these isolated cell suspensions. (3) Plasma membrane fractions were prepared from neurons and glia and the Na+single bondK+-ATPase activity was studied as a function of K+ ion concentration. The glial cell Na+single bondK+-ATPase was always more active, approximately 2.5- to 4-fold, and markedly more sensitive to variations in the K+ ion concentration than the neuronal ATPase. These results support the idea that control of the extracellular K+ ion concentration in the CNS is at least in part dependent on the metabolically coupled sodium-potassium pump of the glial cell.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adenosine Triphosphatases/physiology Animals Biological Transport, Active Brain/*metabolism Buffers Cell Membrane/enzymology Cerebral Cortex/metabolism *Extracellular Space Inulin/metabolism Neuroglia/enzymology/*physiology Neurons/*metabolism Potassium/*metabolism Rabbits Sodium/metabolism Tritium |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | 25 August 1972 |
| Date Deposited: | 09 Jul 2014 18:41 |
| Last Modified: | 09 Jul 2014 18:41 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30200 |
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