Autexier, C., Greider, C. W. (October 1996) Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sci, 21 (10). pp. 387-91. ISSN 0968-0004 (Print)
Abstract
Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Cell Division/genetics Cells, Cultured Eukaryotic Cells/enzymology/metabolism Humans Mice Neoplasms/ physiopathology/therapy Research Support, Non-U.S. Gov't Telomerase/antagonists & inhibitors/ metabolism Telomere/ chemistry/genetics/metabolism |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres |
| CSHL Authors: | |
| Communities: | CSHL labs > Greider lab |
| Depositing User: | Matt Covey |
| Date: | October 1996 |
| Date Deposited: | 22 May 2014 15:44 |
| Last Modified: | 22 May 2014 15:44 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30169 |
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