Programmed cell death in invertebrates

Hengartner, M. O. (February 1996) Programmed cell death in invertebrates. Curr Opin Genet Dev, 6 (1). pp. 34-8. ISSN 0959-437X (Print)

DOI: 10.1016/S0959-437X(96)90007-6


Genetic studies of programmed cell death in Caenorhabditis elegans and Drosophila melanogaster have led to the identification of several invertebrate cell death genes. In C. elegans, ced-3 and ced-4 function to kill cells, whereas ced-9 protects cells from death. In Drosophila, the genes reaper and hid act in parallel to promote cell death. Characterization of these genes has revealed that the process of programmed cell death is evolutionarily conserved and has shed light on the molecular nature of the apoptotic machinery.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis/ genetics Caenorhabditis elegans/ genetics Drosophila/ genetics Humans Invertebrates/genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: organism description > animal > C elegans
organism description > animal > insect > Drosophila
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Matt Covey
Date: February 1996
Date Deposited: 22 May 2014 14:40
Last Modified: 22 May 2014 14:40
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