Genetic analysis of function and dysfunction in the central nervous system

Silva, A. J., Fedorov, N., Kogan, J., Frankland, P., Coblentz, J., Lundsten, R., Friedman, E., Smith, A., Cho, Y., Giese, K. P. (1996) Genetic analysis of function and dysfunction in the central nervous system. Cold Spring Harbor Symposia on Quantitative Biology, 61. pp. 239-46. ISSN 0091-7451 (Print)

DOI: 10.1101/SQB.1996.061.01.026


The last decade has been witness to unprecedented advances in mammalian genetics. Techniques have been developed that allow the addition, deletion, or modification of any cloned gene. Recent developments also promise control over when and where mutations take place. These genetic tools have already been used successfully in the study of learning and memory. The results show that it is possible to derive mutants with informative molecular, cellular, neuroanatomical, and behavioral phenotypes. These findings have both complemented and expanded previous neuroanatomical and pharmacological studies, demonstrating that genetic techniques will be an important tool in developing explanations of learning and memory. Genetic studies of brain function must be developed from a solid behavioral foundation, since the design and interpretation of experiments is dependent on the clarity of the behavioral concepts under analysis. Beyond careful behavioral work, these studies must also include information about the neuroanatomy and physiology of the brain regions...

Item Type: Paper
Uncontrolled Keywords: Animals Central Nervous System/ physiology Central Nervous System Diseases/ genetics Humans Memory/physiology Neuronal Plasticity/genetics/physiology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Transcription Factors/physiology
Subjects: diseases & disorders > nervous system diseases and disorders
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Mainen lab
CSHL labs > Tully lab
Depositing User: Kathleen Darby
Date: 1996
Date Deposited: 12 May 2014 17:53
Last Modified: 12 May 2014 17:53
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