Misteli, T. (1996) The mammalian Golgi apparatus during M-phase. Progress in cell cycle research, 2. pp. 267-77. ISSN 1087-2957 (Print)
Abstract
The Golgi apparatus in mammalian cells disassembles into several thousand vesicles as cells enter M-phase. Disassembly is dependent on the action of cdc2-kinase and at least two pathways contribute to the fragmentation: One involves the budding of COP-coated vesicles from Golgi cisternae with concomitant inhibition of fusion with their target membranes, the other is a less well characterised COP-independent pathway. During telophase, the Golgi fragments reassemble and fuse into a fully functional Golgi stack, using at least two distinct fusion pathways. The morphological changes of the Golgi apparatus during M-phase offer an ideal system to study how cellular organelles are generated and how their structure is maintained during interphase.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals CDC2 Protein Kinase/metabolism Golgi Apparatus/metabolism/ ultrastructure Humans Interphase/physiology Mammals Membrane Fusion/physiology Membrane Proteins/metabolism Microscopy, Electron Mitosis/ physiology |
| Subjects: | organs, tissues, organelles, cell types and functions > organelles, types and functions > golgi organs, tissues, organelles, cell types and functions > tissues types and functions > membranes Investigative techniques and equipment > microscopy organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis |
| CSHL Authors: | |
| Communities: | CSHL labs > Spector lab |
| Depositing User: | Kathleen Darby |
| Date: | 1996 |
| Date Deposited: | 13 May 2014 17:00 |
| Last Modified: | 13 May 2014 17:00 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30090 |
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