Misteli, T. (June 1996) Molecular mechanisms in the disassembly and reassembly of the mammalian Golgi apparatus during M-phase. Febs Letters, 389 (1). pp. 66-9. ISSN 0014-5793
Abstract
The mitotic disassembly and reassembly of the mammalian Golgi apparatus is an ideal system to study the molecular mechanisms involved in biogenesis and maintenance of membranous organelles. As cells enter M-phase, Golgi stacks are converted into Golgi clusters of small membrane fragments, which are dispersed throughout the cytoplasmic space during metaphase. Disassembly is dependent on the action of cdc2-kinase and at least two distinct pathways contribute to the fragmentation: one involves the budding of COP I-coated vesicles from Golgi cisternae, the other is a less well characterised COP I-independent pathway. During telophase, the Golgi fragments reassemble and fuse into a fully functional Golgi stack, using at least two distinct ATPase-mediated fusion pathways.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Golgi Apparatus/metabolism/ physiology Mammals Mitosis/ physiology Research Support, Non-U.S. Gov't |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > ATPase organs, tissues, organelles, cell types and functions > organelles, types and functions > golgi organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis |
| CSHL Authors: | |
| Communities: | CSHL labs > Spector lab |
| Depositing User: | Kathleen Darby |
| Date: | 24 June 1996 |
| Date Deposited: | 13 May 2014 16:53 |
| Last Modified: | 13 May 2014 16:53 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30089 |
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