Long-term potentiation in the CA1 hippocampus

Malinow, R., Mainen, Z. F. (March 1996) Long-term potentiation in the CA1 hippocampus. Science, 271 (5255). pp. 1604-6.

URL: http://www.ncbi.nlm.nih.gov/pubmed/8599121
DOI: 10.1126/science.271.5255.1604


Polarized debate continues regarding the locus of the modification responsible for the enhancement of synaptic transmission during long-term potentiation (LTP) in CAl hippocampus, a widely studied cellular model of learning and memory. Two recent papers (1, 2) have shed light using techniques in which only one or a few axons are stimulated. In this way, transmission may be characterized not only by the mean amplitude of the response (as usual), but also by identifying failures (responses with zero amplitude) and successes of transmission. With LTP, these researchers observe a change in the rate of successes, but no change in the mean amplitude of successes (the "potency").

Item Type: Paper
Additional Information: 0036-8075 (Print) Comment Letter
Uncontrolled Keywords: Animals Hippocampus/*physiology *Long-Term Potentiation Monte Carlo Method Synapses/*physiology *Synaptic Transmission
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Mainen lab
CSHL labs > Malinow lab
Depositing User: Kathleen Darby
Date: 15 March 1996
Date Deposited: 13 May 2014 16:44
Last Modified: 13 May 2014 16:44
Related URLs:
URI: https://repository.cshl.edu/id/eprint/30087

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