Dual functions of the KNOTTED1 homeodomain: sequence-specific DNA binding and regulation of cell-to-cell transport

Bolduc, N., Hake, S., Jackson, D. (2008) Dual functions of the KNOTTED1 homeodomain: sequence-specific DNA binding and regulation of cell-to-cell transport. Science Signaling, 1 (23). pe28.

Abstract

Homeodomain proteins are well-characterized developmental regulators that control expression of target genes through sequence-specific DNA binding. The homeodomain forms a trihelical structure, with the third helix conferring specific interactions with the DNA major groove. A specific class of plant homeodomain proteins, called KNOX [KNOTTED1 (KN1)-like homeobox], also has the ability to signal between cells by directly trafficking through intercellular channels called plasmodesmata. Trafficking is mediated by a signal that is also contained within the homeodomain. Movement protein binding protein 2C was identified as a protein that interacts with the KN1 homeodomain and regulates the cell-to-cell trafficking of KN1 by sequestering the protein on microtubules. Therefore, KN1 has multiple potential cellular addresses, each of which is conferred by its homeodomain.

Item Type:	Paper
Uncontrolled Keywords:	Cell Communication DNA, Plant/*metabolism DNA-Binding Proteins/chemistry/metabolism Homeodomain Proteins/*chemistry/genetics/*metabolism Mutation Plant Proteins/*chemistry/genetics/*metabolism Signal Transduction Solanum tuberosum/enzymology Tobacco/enzymology Transcription, Genetic
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > homeodomain protein organism description > plant organs, tissues, organelles, cell types and functions > tissues types and functions > transport > trans-membrane transport
CSHL Authors:	Jackson, David P.
Communities:	CSHL labs > Jackson lab
Depositing User:	Matt Covey
Date:	2008
Date Deposited:	12 May 2014 14:58
Last Modified:	12 May 2014 14:58
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/30045

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