Medication-free research with schizophrenic patients. A European perspective

Henn, F. A., Lader, M. (May 1997) Medication-free research with schizophrenic patients. A European perspective. Archives of General Psychiatry, 54 (5). pp. 412-3. ISSN 0003-990X (Print)0003-990X (Linking)

DOI: 10.1001/archpsyc.1997.01830170028003


The article by Carpenter et al in this issue of the ARCHIVES presents a clear evaluation of the role of medication-free research in schizophrenia and discusses the ethical implications of such research. The authors argue that medication-free research offers distinct advantages in treatment trials and that the risks for relapse can be limited through careful patient selection, close clinical monitoring, and psychosocial treatments. They further discuss the role of medication-free research in probing questions concerning etiology and provide some assessment of the issues in determining the risk-to-benefit ratio in these cases. They also suggest some relevant guidelines for patient selection in carrying out medication-free research. Finally, they provide some thoughtful insights on the issue of informed consent.

Item Type: Paper
Uncontrolled Keywords: Antipsychotic Agents/ therapeutic use Clinical Protocols/standards Clinical Trials as Topic/standards Ethics, Medical Europe Humans Mentally Ill Persons Patient Advocacy Placebos Research Design/ standards Risk Assessment Schizophrenia/drug therapy Withholding Treatment
Subjects: diseases & disorders > mental disorders > schizophrenia
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Kathleen Darby
Date: May 1997
Date Deposited: 08 May 2014 15:21
Last Modified: 08 May 2014 15:21
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