Zhang, M. Q. (1998) A discrimination study of human core-promoters. Pacific Symposium on Biocomputing. pp. 240-51.
Abstract
A core-promoter, approximately from -60 bp upstream to +40 bp downstream of a RNA polymerase (RNAP) II transcription start site (TSS), binds to the preinitiation complex (PIC) and determine the position of TSS. Using position-specific k-tuple feature variables, a quadratic discriminant analysis (QDA) method is shown to be very effective in identifying human core-promoters.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Base Sequence Binding Sites Computational Biology/ methods Discriminant Analysis Humans Molecular Sequence Data Promoter Regions (Genetics) RNA Polymerase II/ genetics/ metabolism Reproducibility of Results Research Support, U.S. Gov't, P.H.S. Software TATA Box Transcription Factors/metabolism Transcription, Genetic |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > RNA polymerase bioinformatics > computational biology bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhang lab |
| Depositing User: | Kathleen Darby |
| Date: | 1998 |
| Date Deposited: | 30 Apr 2014 20:27 |
| Last Modified: | 30 Apr 2014 20:27 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29945 |
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