Nedivi, E., Wu, G. Y., Cline, H. T. (September 1998) Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Science, 281 (5384). pp. 1863-6. ISSN 0036-8075 (Print)
Abstract
Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Dendrites/ physiology/ultrastructure Genetic Vectors Glycosylphosphatidylinositols/metabolism Image Processing, Computer-Assisted Interneurons/cytology/physiology Ligands Membrane Proteins/genetics/metabolism/ physiology Microscopy, Confocal Nerve Tissue Proteins Neuronal Plasticity Neurons/cytology/physiology Recombinant Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Signal Transduction Superior Colliculus/cytology/metabolism Vaccinia virus/genetics/physiology Xenopus laevis |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons bioinformatics > genomics and proteomics > small molecules > cofactors > ligands organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction organism description > animal > Frog > xenopus |
| CSHL Authors: | |
| Communities: | CSHL labs > Cline lab CSHL labs > Stillman lab |
| Depositing User: | Kathleen Darby |
| Date: | 18 September 1998 |
| Date Deposited: | 01 May 2014 14:11 |
| Last Modified: | 01 May 2014 14:11 |
| PMCID: | PMC3088013 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29919 |
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