Tabaska, J. E., Zhang, M. Q. (April 1999) Detection of polyadenylation signals in human DNA sequences. Gene, 231 (1-2). pp. 77-86. ISSN 0378-1119 (Print)
Abstract
We present polyadq, a program for detection of human polyadenylation signals. To avoid training on possibly flawed data, the development of polyadq began with a de novo characterization of human mRNA 3' processing signals. This information was used in training two quadratic discriminant functions that polyadq uses to evaluate potential polyA signals. In our tests, polyadq predicts polyA signals with a correlation coefficient of 0.413 on whole genes and 0.512 in the last two exons of genes, substantially outperforming other published programs on the same data set. polyadq is also the only program that is able to consistently detect the ATTAAA variant of the polyA signal.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | DNA/ genetics Humans Poly A/ metabolism RNA Processing, Post-Transcriptional Research Support, Non-U.S. Gov't Signal Transduction |
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhang lab |
| Depositing User: | Kathleen Darby |
| Date: | 29 April 1999 |
| Date Deposited: | 28 Apr 2014 16:21 |
| Last Modified: | 28 Apr 2014 16:21 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29816 |
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