Petralia, R. S., Esteban, J. A., Wang, Y. X., Partridge, J. G., Zhao, H. M., Wenthold, R. J., Malinow, R. (January 1999) Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nature Neuroscience, 2 (1). pp. 31-6.
Abstract
Early in postnatal development, glutamatergic synapses transmit primarily through NMDA receptors. As development progresses, synapses acquire AMPA receptor function. The molecular basis of these physiological observations is not known. Here we examined single excitatory synapses with immunogold electron-microscopic analysis of AMPA and NMDA receptors along with electrophysiological measurements. Early in postnatal development, a significant fraction of excitatory synapses had NMDA receptors and lacked AMPA receptors. As development progressed, synapses acquired AMPA receptors with little change in NMDA receptor number. Thus, synapses with NMDA receptors but no AMPA receptors can account for the electrophysiologically observed 'silent synapse'.
| Item Type: | Paper |
|---|---|
| Additional Information: | 1097-6256 (Print) Journal Article |
| Uncontrolled Keywords: | Aging/*metabolism Animals Animals, Newborn/growth & development/*metabolism Electrophysiology Hippocampus/growth & development/*metabolism Immunohistochemistry Male Microscopy, Electron Rats Rats, Sprague-Dawley Receptors, AMPA/*metabolism Receptors, N-Methyl-D-Aspartate/metabolism Synapses/*physiology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor Investigative techniques and equipment > electrophysiology organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus Investigative techniques and equipment > microscopy organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse |
| CSHL Authors: | |
| Communities: | CSHL labs > Malinow lab |
| Depositing User: | Kathleen Darby |
| Date: | January 1999 |
| Date Deposited: | 30 Apr 2014 14:34 |
| Last Modified: | 30 Apr 2014 14:34 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29806 |
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