Noradrenergic induction of odor-specific neural habituation and olfactory memories

Shea, S. D., Katz, L. C., Mooney, R. (October 2008) Noradrenergic induction of odor-specific neural habituation and olfactory memories. Journal of Neuroscience, 28 (42). pp. 10711-9. ISSN 0270-6474

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DOI: 10.1523/jneurosci.3853-08.2008


For many mammals, individual recognition of conspecifics relies on olfactory cues. Certain individual recognition memories are thought to be stored when conspecific odor cues coincide with surges of noradrenaline (NA) triggered by intensely arousing social events. Such familiar stimuli elicit reduced behavioral responses, a change likely related to NA-dependent plasticity in the olfactory bulb (OB). In addition to its role in these ethological memories, NA signaling in the OB appears to be relevant for the discrimination of more arbitrary odorants as well. Nonetheless, no NA-gated mechanism of long-term plasticity in the OB has ever been directly observed in vivo. Here, we report that NA release from locus ceruleus (LC), when coupled to odor presentation, acts locally in the main OB to cause a specific long-lasting suppression of responses to paired odors. These effects were observed for both food odors and urine, an important social recognition cue. Moreover, in subsequent behavioral tests, mice exhibited habituation to paired urine stimuli, suggesting that this LC-mediated olfactory neural plasticity, induced under anesthesia, can store an individual recognition memory that is observable after recovery.

Item Type: Paper
Uncontrolled Keywords: Animals Female Habituation, Psychophysiologic/*physiology Locus Coeruleus/metabolism/secretion Male Memory/*physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Norepinephrine/metabolism/*secretion *Odors Olfactory Bulb/physiology Olfactory Pathways/*physiology Smell/*physiology
Subjects: organism description > animal behavior
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > norepinephrine
organism description > animal behavior > odor recognition
organism description > animal behavior > olfactory
CSHL Authors:
Communities: CSHL labs > Shea lab
Depositing User: Matt Covey
Date: 15 October 2008
Date Deposited: 19 Feb 2014 17:54
Last Modified: 19 Feb 2014 17:54
PMCID: PMC2588668
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