Grewal, S. I. S. (September 2000) Transcriptional silencing in fission yeast. Journal of Cellular Physiology, 184 (3). pp. 311-318. ISSN 0021-9541
Abstract
In eukaryotes, epigenetic events govern diverse processes, ranging from gene expression to other aspects of global chromosome architecture essential for preserving the integrity of the genome. Transcriptional silencing at the mating-type locus, centromeres, and telomeres of the fission yeast is regulated by epigenetic mechanisms. Epigenetic states are inherited in cis during mitosis and, remarkably, even through meiosis. Several trans-acting genes that affect silencing are found to encode either chromatin proteins such as chromodomain proteins Swi6 and Clr4 or the factors that affect chromatin assembly, including histone deacetylase homologs Clr3 and Clr6. A recent study showed that Swi6 is involved in imprinting at the mating-type locus and contributes to the cellular memory responsible for maintenance of the silenced state. The "gene" in this instance thus comprises DNA plus the associated Swi6-containing protein complex, J. Cell. Physiol. 184:311-318, 2000.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | POSITION-EFFECT VARIEGATION MATING-TYPE REGION DISRUPT CHROMOSOME SEGREGATION SWITCHING GENE SWI6 SCHIZOSACCHAROMYCES-POMBE EPIGENETIC INHERITANCE MEIOTIC RECOMBINATION S-POMBE CENTROMERE FUNCTION DNA METHYLATION |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Grewal lab |
| Depositing User: | Matt Covey |
| Date: | September 2000 |
| Date Deposited: | 28 Jan 2014 21:49 |
| Last Modified: | 28 Jan 2014 21:49 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29453 |
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