Proteomics: new perspectives, new biomedical opportunities

Banks, R. E., Dunn, M. J., Hochstrasser, D. F., Sanchez, J. C., Blackstock, W., Pappin, D. J., Selby, P. J. (November 2000) Proteomics: new perspectives, new biomedical opportunities. Lancet, 356 (9243). pp. 1749-56. ISSN 0140-6736 (Print)0140-6736 (Linking)

DOI: 10.1016/s0140-6736(00)03214-1


Proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, complement the genome initiatives and are increasingly being used to address biomedical questions. Proteins are the main functional output, and the genetic code cannot always indicate which proteins are expressed, in what quantity, and in what form. For example, post-translational modifications of proteins, such as phosphorylation or glycosylation, are very important in determining protein function. Similarly, the effects of environmental factors or multigenic processes such as ageing or disease cannot be assessed simply by examination of the genome alone. This review describes the underlying technology and illustrates several areas of biomedical research, ranging from pathogenesis of neurological disorders to drug and vaccine design, in which potential clinical applications are being explored.

Item Type: Paper
Uncontrolled Keywords: Animals Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Humans Information Systems Protein Processing, Post-Translational Proteome/ analysis/genetics Research
Subjects: bioinformatics > genomics and proteomics
CSHL Authors:
Communities: CSHL labs > Pappin lab
Depositing User: Matt Covey
Date: 18 November 2000
Date Deposited: 30 Jan 2014 16:20
Last Modified: 30 Jan 2014 16:20
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