DeZazzo, J., Sandstrom, D., de Belle, S., Velinzon, K., Smith, P., Grady, L., DelVecchio, M., Ramaswami, M., Tully, T. (July 2000) nalyot, a mutation of the Drosophila Myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory. Neuron, 27 (1). pp. 145-158. ISSN 0896-6273
Abstract
nalyot (nal) is a novel olfactory memory mutant of Drosophila, encoding Adf1, a myb-related transcription factor. Following extended training sessions, Adf1 mutants show normal early memory but defective longterm memory. Adf1 shows widespread spatiotemporal expression, yet mutant alleles reveal no discernible disruptions in gross morphology of the nervous system. Studies at the larval neuromuscular junction, however, reveal a role for Adf1 in the modulation of synaptic growth-in contrast to the role established for dCREB2 in the control of synaptic function (Davis et at., 1996). These findings suggest that Adf1 and dCREB2 regulate distinct transcriptional cascades involved in terminal stages of synapse maturation. More generally, Adf1 provides a novel link between molecular mechanisms of developmental and behavioral plasticity.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | LONG-TERM FACILITATION MUSHROOM BODIES GENETIC DISSECTION MELANOGASTER EXPRESSION ENCODES LATHEO MUTANT CREB IDENTIFICATION |
| Subjects: | organism description > animal > insect > Drosophila organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb organs, tissues, organelles, cell types and functions > tissues types and functions > synaptogenesis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab |
| Depositing User: | Matt Covey |
| Date: | July 2000 |
| Date Deposited: | 30 Jan 2014 21:27 |
| Last Modified: | 30 Jan 2014 21:27 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29420 |
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