Zaman, S. H., Parent, A., Laskey, A., Lee, M. K., Borchelt, D. R., Sisodia, S. S., Malinow, R. (February 2000) Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiology of Disease, 7 (1). pp. 54-63. ISSN 0969-9961
Abstract
Mutations in presenilin 1(PS1) are the most common causes of familial Alzheimer's disease (FAD). We examined synaptic physiology in hippocampal brain slices of transgenic mice expressing the FAD-linked PS1 deletion of exon 9 variant. Basal excitatory transmission and paired-pulse facilitation in PS1 mutant mice were unchanged. Short- and long-term potentiation of excitatory transmission following high-frequency stimulation were greater in transgenic mice expressing mutant PS1. Mutants had enhanced synaptic inhibition, which may be a compensatory change offsetting an abnormally sensitized plasticity of excitatory transmission. Increasing inhibitory transmission in mutant animals even more with a benzodiazepine reverted synaptic potentiation to the levels of controls. These results support the potential use of benzodiazepines in the treatment of familial Alzheimer's disease.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | LONG-TERM POTENTIATION AMYLOID PRECURSOR PROTEIN IN-VIVO ENDOPLASMIC-RETICULUM BETA-PEPTIDE LOCALIZATION MEMORY CELLS BRAIN HIPPOCAMPUS |
| Subjects: | diseases & disorders > mental disorders > delirium dementia cognitive disorders > Alzheimer's disease Investigative techniques and equipment > electrophysiology > brain slice Investigative techniques and equipment > electrophysiology organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission |
| CSHL Authors: | |
| Communities: | CSHL labs > Malinow lab |
| Depositing User: | Matt Covey |
| Date: | February 2000 |
| Date Deposited: | 31 Jan 2014 16:17 |
| Last Modified: | 31 Jan 2014 16:17 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29384 |
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