Cortical response to motor stimulation in neuroleptic-naive first episode schizophrenics

Braus, D. F., Ende, G., Hubrich-Ungureanu, P., Henn, F. A. (May 2000) Cortical response to motor stimulation in neuroleptic-naive first episode schizophrenics. Psychiatry Res, 98 (3). pp. 145-54. ISSN 0165-1781 (Print)0165-1781 (Linking)

DOI: 10.1016/S0925-4927(00)00046-9


The purpose of the present study was to evaluate the cortical response to motor stimulation in neuroleptic-naive first episode schizophrenics in comparison to matched controls using a high speed functional magnetic resonance imaging technique (fMRI). Twelve patients satisfying ICD 10 criteria (F20.0) for schizophrenia (paranoid subtype) as well as sex- and age-matched healthy volunteers participated in this study. All subjects underwent fMRI examination on a conventional 1.5 T MR unit equipped with an echo-planar imaging booster. The blood oxygen level dependent (BOLD) response of the sensorimotor cortex and the higher order SMA region was evaluated during performance of a left hand sequential finger opposition task. Special care was taken to minimize performance and motion artifacts. Patients and controls showed no notable difference with respect to laterality, changes of signal intensity or spatial extent of activation within the primary and higher order motor regions. Using high speed fMRI no fundamental motor cortical dysfunction was evident in a group of paranoid neuroleptic-naive first episode schizophrenic patients. In contrast to data previously reported for chronic disorganized medicated patients, these results suggest that motor dysfunction is not part of the phenomenology of acute paranoid first episode patients.

Item Type: Paper
Uncontrolled Keywords: Acute Disease Adult Case-Control Studies Dominance, Cerebral Echo-Planar Imaging Female Humans Male Motor Cortex/ pathology/physiopathology Motor Skills Schizophrenia, Paranoid/ pathology/physiopathology
Subjects: diseases & disorders > mental disorders > schizophrenia
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 15 May 2000
Date Deposited: 31 Jan 2014 20:24
Last Modified: 31 Jan 2014 20:24
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