Shi, S. H., Hayashi, Y., Esteban, J. A., Malinow, R.
(May 2001)
Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.
Cell, 105 (3).
pp. 331-343.
ISSN 0092-8674
Abstract
AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are heterooligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/ GluR2 receptors are added to synapses during plasticity; this requires interactions between GluR1 and group I PDZ domain proteins. In contrast, GluR2/GluR3 receptors replace existing synaptic receptors continuously; this occurs only at synapses that already have AMPA-Rs and requires interactions by GluR2 with NSF and group I! PDZ domain proteins. The combination of regulated addition and continuous replacement of synaptic receptors can stabilize long-term changes in synaptic efficacy and may serve as a general model for how surface receptor number is established and maintained.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
LONG-TERM POTENTIATION
DOMAIN-CONTAINING PROTEIN
MEDIATED
GENE-TRANSFER
SYNAPTIC PLASTICITY
GLUTAMATE RECEPTORS
SILENT
SYNAPSES
POSTSYNAPTIC EXPRESSION
BRAIN-SLICES
PDZ DOMAINS
LTP |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Malinow lab |
| Depositing User: |
Matt Covey
|
| Date: |
May 2001 |
| Date Deposited: |
16 Jan 2014 16:57 |
| Last Modified: |
16 Jan 2014 16:57 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29304 |
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