Foa, L., Rajan, I., Haas, K., Wu, G. Y., Brakeman, P., Worley, P., Cline, H. (May 2001) The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo. Nature Neuroscience, 4 (5). pp. 499-506. ISSN 1097-6256
Abstract
Homer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein-protein interactions. We tested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type and mutant isoforms of Homer in Xenopus optic tectal neurons. Time-lapse imaging demonstrated that interfering with the ability of endogenous Homer to form protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points. These data demonstrate a function for scaffold proteins such as Homer in axon guidance. Homer may facilitate signal transduction from cell-surface receptors to intracellular proteins that govern the establishment of axon trajectories.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | METABOTROPIC GLUTAMATE RECEPTORS GROWTH CONES GRANULE CELLS SMALL GTPASES CALCIUM GUIDANCE FAMILY CYTOSKELETON DROSOPHILA MOLECULES |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification organs, tissues, organelles, cell types and functions > tissues types and functions > axon organism description > animal > Frog > xenopus |
| CSHL Authors: | |
| Communities: | CSHL labs > Cline lab |
| Depositing User: | Matt Covey |
| Date: | May 2001 |
| Date Deposited: | 22 Jan 2014 17:24 |
| Last Modified: | 22 Jan 2014 17:24 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29233 |
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