Lower concentration of thalamic n-acetylaspartate in patients with schizophrenia: a replication study

Ende, G., Braus, D. F., Walter, S., Henn, F. A. (August 2001) Lower concentration of thalamic n-acetylaspartate in patients with schizophrenia: a replication study. Am J Psychiatry, 158 (8). pp. 1314-6. ISSN 0002-953X (Print)0002-953X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11481168
DOI: 10.1176/appi.ajp.158.8.1314


OBJECTIVE: Using proton magnetic resonance spectroscopic imaging, the authors measured thalamic N-acetylaspartate (NAA) concentrations in patients with schizophrenia. METHOD: The study included 15 schizophrenic patients on a stable medication regimen and 15 age-matched healthy comparison subjects. Concentrations of NAA, creatine plus phosphocreatine, and choline-containing compounds in bilateral thalamic regions were determined. RESULTS: Previous findings of lower NAA concentration in the left and right mediodorsal region of the thalamus and significant correlations between left and right thalamic NAA measures in patients with schizophrenia were corroborated. Furthermore, the concentrations of choline-containing compounds were significantly lower in the schizophrenic patients. No group differences in creatine plus phosphocreatine were found. CONCLUSIONS: There is strong evidence for neuronal dysfunction or loss in the mediodorsal region of the thalamus in patients with schizophrenia.

Item Type: Paper
Uncontrolled Keywords: Adult Aspartic Acid/analogs & derivatives/ analysis Choline/analysis Female Functional Laterality Humans Magnetic Resonance Imaging/statistics & numerical data Magnetic Resonance Spectroscopy/statistics & numerical data Male Phosphocreatine/analysis Schizophrenia/ diagnosis/metabolism/physiopathology Thalamus/ chemistry/physiopathology
Subjects: diseases & disorders > mental disorders
diseases & disorders > mental disorders > schizophrenia
Investigative techniques and equipment > spectroscopy > magnetic resonance spectroscopy
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: August 2001
Date Deposited: 22 Jan 2014 16:56
Last Modified: 22 Jan 2014 16:56
Related URLs:
URI: https://repository.cshl.edu/id/eprint/29231

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