Peunova, N., Kuzin, B., Roberts, I., Okane, C., Enikolopov, G. (1996) Nitric oxide, cell multiplication, and cell survival. Cold Spring Harbor Symposia on Quantitative Biology, 61. pp. 417-426. ISSN 0091-7451
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Abstract
Arrest of cell division is crucial for cells to enter a program of terminal differentiation. In the developing organ or a differentiating tissue, growth arrest defines roughly the size of the cellular population that is further committed to become a domain of differentiated cells. Eventually, the balance between the number of cell divisions and the extent of subsequent programmed cell death determines the final size of a domain, a tissue, or an organ (for review, see Bryant and Simpson 1984; Raff 1992, 1996). Mitogenesis, cytostasis, and survival of neuronal cells can be induced and maintained by the same or by different growth or trophic factors. The signaling pathways that coordinate proliferation, growth arrest, and survival of cells and groups of cells in developing organisms are not known, but they probably involve as yet undetermined inter- and intra-cellular second messenger molecules.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | NERVE GROWTH-FACTOR PC12 PHEOCHROMOCYTOMA CELLS NADPH-DIAPHORASE STRIATAL NEURONS RIBONUCLEOTIDE REDUCTASE SELECTIVELY RESISTANT HUNTINGTONS-DISEASE DEATH EXPRESSION DROSOPHILA |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation bioinformatics > genomics and proteomics > small molecules > nitric oxide |
| CSHL Authors: | |
| Communities: | CSHL labs > Enikopolov lab |
| Depositing User: | Matt Covey |
| Date: | 1996 |
| Date Deposited: | 20 Dec 2013 16:02 |
| Last Modified: | 20 Dec 2013 16:02 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29139 |
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