A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia

Weber-Fahr, W., Ende, G., Braus, D. F., Bachert, P., Soher, B. J., Henn, F. A., Buchel, C. (May 2002) A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia. Neuroimage, 16 (1). pp. 49-60. ISSN 1053-8119 (Print)1053-8119 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11969317
DOI: 10.1006/nimg.2002.1057


In this report, we describe the implementation and application of a fully automated segmentation routine using SPM99 algorithms and MATLAB for clinical Magnetic Resonance Spectroscopic Imaging (MRSI) studies. By segmenting high-resolution 3-D image data and coregistering the results to the spatial localizer slices of a spectroscopy examination, the program offers the possibility to easily calculate segmentation maps for a large variety of MRSI experiments. The segmented data are corrected for the individual point-spread function, slice and VOI profiles for measurement sequences with selective pulses as well as for the chemical shifts of different metabolites. The new method was applied to investigate discrete hippocampal metabolite abnormalities in a small sample of schizophrenic patients in comparison to healthy controls (15 patients, 15 controls). Only after correction was the N-acetyl-aspartate (NAA) signal significantly lower in patients compared to controls. No differences were found for the corrected signals from the creatine/phosphocreatine (Cr) or choline-containing compounds (Ch). These results are in good agreement with neuropathological and previous MR spectroscopy studies of the hippocampus in schizophrenic patients.

Item Type: Paper
Uncontrolled Keywords: Adult Algorithms Aspartic Acid/ analogs & derivatives/ cerebrospinal fluid/ metabolism Choline/cerebrospinal fluid/metabolism Creatine/cerebrospinal fluid/metabolism Female Hippocampus/metabolism/ pathology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Phosphocreatine/cerebrospinal fluid/metabolism Schizophrenia/ cerebrospinal fluid/ pathology
Subjects: diseases & disorders
diseases & disorders > mental disorders > schizophrenia
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
Investigative techniques and equipment > spectroscopy > magnetic resonance spectroscopy
Investigative techniques and equipment > spectroscopy
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: May 2002
Date Deposited: 30 Oct 2013 16:43
Last Modified: 30 Oct 2013 16:43
Related URLs:
URI: https://repository.cshl.edu/id/eprint/28810

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving