Sin, W. C., Haas, K., Ruthazer, E. S., Cline, H. T.
(October 2002)
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases.
Nature, 419 (6906).
pp. 475-480.
ISSN 0028-0836
Abstract
Previous studies suggest that neuronal activity may guide the development of synaptic connections in the central nervous system through mechanisms involving glutamate receptors and GTPase-dependent modulation of the actin cytoskeleton. Here we demonstrate by in vivo time-lapse imaging of optic tectal cells in Xenopus laevis tadpoles that enhanced visual activity driven by a light stimulus promotes dendritic arbor growth. The stimulus-induced dendritic arbor growth requires glutamate-receptor-mediated synaptic transmission, decreased RhoA activity and increased Rac and Cdc42 activity. The results delineate a role for Rho GTPases in the structural plasticity driven by visual stimulation in vivo.
| Item Type: |
Paper
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| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organism description > animal > Frog > xenopus |
| CSHL Authors: |
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| Communities: |
CSHL labs > Cline lab |
| Depositing User: |
Matt Covey
|
| Date: |
October 2002 |
| Date Deposited: |
31 Oct 2013 16:54 |
| Last Modified: |
31 Oct 2013 16:54 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/28788 |
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