Genomics: More than the sum of the parts

Rabinowicz, P. D., Scahidanandam, R. (July 2002) Genomics: More than the sum of the parts. Genome Research, 12 (7). pp. 1015-1016. ISSN 1088-9051

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DOI: 10.1101/gr.432502


It has been known for some time that DNA composition varies across a given genome as well as between genomes (Filipski et al. 1973;Wagner and Capesius 1981). Genomic sequencing projects allow this observation to be confirmed at the sequence level (The Arabidopsis Genome Initiative 2000; Ashikawa 2001). However, the cause and function of these compositional differences are still obscure. Among the theories that may explain these phenomena (Eyre-Walker and Hurst 2001), mutation bias from C to T due to deamination of methylated C has been commonly used to account for them (Coulondre et al. 1978). As methylation is probably involved in a mechanism to silence transposable elements (Martienssen 1998), it makes sense that inactive methylated transposons can easily undergo C to T transition because they are under no selective pressure. However, this theory cannot explain other related compositional biases such as the CpG suppression observed in animal mitochondria (Cardon et al. 1994), where there is no DNA methylation.

Item Type: Paper
Subjects: bioinformatics
bioinformatics > genomics and proteomics
CSHL Authors:
Communities: CSHL labs > Sachidanandam lab
Depositing User: Matt Covey
Date: July 2002
Date Deposited: 31 Oct 2013 21:04
Last Modified: 31 Oct 2013 21:04
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