Inhibition of inhibition in visual cortex: The logic of connections between molecularly distinct interneurons

Pfeffer, C. K., Xue, M., He, M., Huang, Z. J., Scanziani, M. (August 2013) Inhibition of inhibition in visual cortex: The logic of connections between molecularly distinct interneurons. Nature Neuroscience, 16 (8). pp. 1068-1076. ISSN 10976256

Abstract

Cortical inhibitory neurons contact each other to form a network of inhibitory synaptic connections. Our knowledge of the connectivity pattern underlying this inhibitory network is, however, still incomplete. Here we describe a simple and complementary interaction scheme between three large, molecularly distinct interneuron populations in mouse visual cortex: parvalbumin-expressing interneurons strongly inhibit one another but provide little inhibition to other populations. In contrast, somatostatin-expressing interneurons avoid inhibiting one another yet strongly inhibit all other populations. Finally, vasoactive intestinal peptide–expressing interneurons preferentially inhibit somatostatin-expressing interneurons. This scheme occurs in supragranular and infragranular layers, suggesting that inhibitory networks operate similarly at the input and output of the visual cortex. Thus, as the specificity of connections between excitatory neurons forms the basis for the cortical canonical circuit, the scheme described here outlines a standard connectivity pattern among cortical inhibitory neurons.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	He, Miao Huang, Z. Josh
Communities:	CSHL labs > Huang lab
Depositing User:	Matt Covey
Date:	August 2013
Date Deposited:	17 Sep 2013 19:03
Last Modified:	17 Sep 2013 19:03
PMCID:	PMC3729586
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/28619

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