Lineage-specific laminar organization of cortical GABAergic interneurons

Ciceri, G., Dehorter, N., Sols, I., Huang, Z. J., Maravall, M., Marín, O. (August 2013) Lineage-specific laminar organization of cortical GABAergic interneurons. Nature Neuroscience, 16 (9). pp. 1199-1210. ISSN 10976256

URL: http://www.ncbi.nlm.nih.gov/pubmed/23933753

DOI: 10.1038/nn.3485

Abstract

In the cerebral cortex, pyramidal cells and interneurons are generated in distant germinal zones, and so the mechanisms that control their precise assembly into specific microcircuits remain an enigma. Here we report that cortical interneurons labeled at the clonal level do not distribute randomly but rather have a strong tendency to cluster in the mouse neocortex. This behavior is common to different classes of interneurons, independently of their origin. Interneuron clusters are typically contained within one or two adjacent cortical layers, are largely formed by isochronically generated neurons and populate specific layers, as revealed by unbiased hierarchical clustering methods. Our results suggest that different progenitor cells give rise to interneurons populating infra- and supragranular cortical layers, which challenges current views of cortical neurogenesis. Thus, specific lineages of cortical interneurons seem to be produced to primarily mirror the laminar structure of the cerebral cortex, rather than its columnar organization.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > organs types and functions
CSHL Authors:	Huang, Z. Josh
Depositing User:	Matt Covey
Date:	11 August 2013
Date Deposited:	17 Sep 2013 19:08
Last Modified:	25 Sep 2013 15:37
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/28601

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