Soll, D. R., Galask, R., Isley, S., Rao, T. V. G., Stone, D., Hicks, J., Schmid, J., Mac, K., Hanna, C. (1989) Switching of Candida albicans during successive episodes of recurrent vaginitis. Journal of Clinical Microbiology, 27 (4). pp. 681-690. ISSN 00951137 (ISSN)
Abstract
Strain relatedness and switching were monitored in Candida albicans strains isolated from different body locations through three episodes of recurrent vulvovaginal candidiasis selparated by two treatment-latency periods in a single patient. Strain relatedness was assessed by comparing Southern blot hybridization patterns with the relatively immobile mid-repeat sequence Ca3. The following conclusions are demonstrated. (i) Three different strains of C. albicans colonized the mouth, the area under the breasts, and the vulvovaginal, anal, and rectal regions, respectively, at the time of the first infection. (ii) The same strain of C. albicans was responsible for the three vaginal infections. (iii) Switching of colony phenotype occurred with each new vaginal infection. (iv) Enrichment of drug-resistant switch phenotypes (assessed in vitro) was unlikely the basis for the changes in the switch phenotypes of the strain found in the vulvovaginal, anal, and rectal areas after treatment of the first infection with clotrimazole. (v) The same strain of C. albicans was responsible for the recurrent increases in mouth colonization and was distinct from the recurrent vaginal strain. The results of this case study demonstrate the need for the further detailed analyses of full-body mycofloras, strain relatedness, switching repertoires, and changes in drug susceptibility during successive episodes of recurrent vulvovaginal candidiasis.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | antifungal agent butoconazole clotrimazole antibiotic sensitivity dna hybridization fungus human immunoblotting morphology phenotype priority journal recurrent infection strain difference vagina candidiasis Antifungal Agents Blotting, Southern Candida albicans Candidiasis, Vulvovaginal Case Report DNA, Fungal Female Imidazoles Microbial Sensitivity Tests Recurrence Repetitive Sequences, Nucleic Acid Species Specificity Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. |
| Subjects: | diseases & disorders organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Hicks lab |
| Depositing User: | Matt Covey |
| Date: | 1989 |
| Date Deposited: | 09 Aug 2013 20:56 |
| Last Modified: | 12 Aug 2013 14:28 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28508 |
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