Migration of Foxp3+ regulatory T-lymphocytes is stopped in response to hypoxia.

Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. (2008) Migration of Foxp3+ regulatory T-lymphocytes is stopped in response to hypoxia. [Video]

Video (Flash) (Movie)
Egeblad_Movie_13.flv - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (978kB)

URL: http://egebladlab.cshl.edu/movies.html

Abstract

Migration of Foxp3+ regulatory T-lymphocytes is stopped in response to hypoxia. Regulatory T-lymphocytes (green), expressing EGFP as a fusion protein with the transcription factor Foxp3, are seen migrating in a live MMTV-PyMT;ACTB-ECFP;Foxp3EGFP mouse. The same field is shown during normoxia (21% inhaled oxygen), hypoxia (7% inhaled oxygen) and re-established normoxia (21% oxygen). Cancer cells are labeled blue. From Egeblad et al. (2008) Dis. Model. Mech., 1 155-167.

Item Type:	Video
Subjects:	diseases & disorders > cancer diseases & disorders Investigative techniques and equipment organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions Investigative techniques and equipment > microscopy > flourescence microscopy Investigative techniques and equipment > microscopy > immunoflourescence microscopy Investigative techniques and equipment > microscopy organs, tissues, organelles, cell types and functions
CSHL Authors:	Egeblad, Mikala
Communities:	CSHL labs > Egeblad lab
Depositing User:	Matt Covey
Date:	2008
Date Deposited:	26 Apr 2013 16:39
Last Modified:	26 Apr 2013 16:39
Related URLs:	Author
URI:	https://repository.cshl.edu/id/eprint/28268

Actions (login required)

Administrator's edit/view item