Analysis of complex bursting in cortical pyramidal neuron models

Kepecs, A., Wang, X. J. (2000) Analysis of complex bursting in cortical pyramidal neuron models. Neurocomputing, 32-33. pp. 181-187. ISSN 09252312 (ISSN)

Abstract

Burst firing is a prominent feature of cortical pyramidal cells and is thought to have significant functional roles in reliable signaling and synaptic plasticity. Modeling studies have successfully elucidated possible biophysical mechanisms underlying complex bursting in pyramidal cells. Based on these results (Pinsky, Rinzel, J. Comput. Neurosci. 1 (1994) 39-60), we have built a simplified two-compartment burst model. Using the fast- and slow-variable analysis method, we show that complex bursting is an instance of square-wave bursting, where the dendritic slow potassium conductance is the single slow variable. The coupling parameters between the two compartments change the topological class of bursting thereby altering the firing patterns of the neuron. These results explain the diverse set of firing patterns seen with different dendritic morphologies (Mainen, Sejnowski, Nature 382 (1996) 363-366). (C) 2000 Elsevier Science B.V. All rights reserved. Burst firing is a prominent feature of cortical pyramidal cells and is thought to have significant functional roles in reliable signaling and synaptic plasticity. Modeling studies have successfully elucidated possible biophysical mechanisms underlying complex bursting in pyramidal cells. Based on these results (Pinsky, Rinzel, J. Comput. Neurosci. 1 (1994) 39-60), we have built a simplified two-compartment burst model. Using the fast- and slow-variable analysis method, we show that complex bursting is an instance of square-wave bursting, where the dendritic slow potassium conductance is the single slow variable. The coupling parameters between the two compartments change the topological class of bursting thereby altering the firing patterns of the neuron. These results explain the diverse set of firing patterns seen with different dendritic morphologies (Mainen, Sejnowski, Nature 382 (1996) 363-366).

Item Type:	Paper
Uncontrolled Keywords:	Bifurcation diagram Complex burst Phase-plane analysis Bifurcation (mathematics) Bioelectric potentials Biomechanics Cell membranes Computer simulation Differential equations Mathematical models Topology Complex bursting Cortical pyramidal neuron Phase plane analysis Neural networks analytic method article biophysics brain cortex compartment model controlled study dendrite morphology nerve cell plasticity nerve conduction parameter potassium conductance priority journal pyramidal nerve cell signal transduction
Subjects:	organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types bioinformatics > genomics and proteomics > computers > computer software organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
CSHL Authors:	Kepecs, Adam
Communities:	CSHL labs > Kepecs lab
Depositing User:	Matt Covey
Date:	2000
Date Deposited:	10 Apr 2013 20:28
Last Modified:	10 Apr 2013 20:28
URI:	https://repository.cshl.edu/id/eprint/28111

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