Tegnér, J., Kepecs, A. (2002) An adaptive spike-timing-dependent plasticity rule. Neurocomputing, 44-46. pp. 189-194. ISSN 09252312 (ISSN)
Abstract
We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic firing rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD/LTP ratio or pre-synaptic input rates can lead to high firing rates. We propose an adaptive scheme to dynamically control the LTP/LTD ratio. The biophysics of synapses lead us to suggest a control mechanism using action potential-induced calcium influx, a known mediator of synaptic plasticity. This adaptive STDP rule is shown to stabilize the post-synaptic firing rates under a variety of perturbations. © 2002 Published by Elsevier Science B.V.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Hebbian Homeostatic mechanisms Learning Spike correlations Calcium Computer simulation Perturbation techniques Plasticity Post-synaptic firing rates Neurology action potential article biophysics calcium transport controlled study nerve cell plasticity postsynaptic potential presynaptic potential priority journal spike wave synapse |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal behavior > learning organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission |
| CSHL Authors: | |
| Communities: | CSHL labs > Kepecs lab |
| Depositing User: | Matt Covey |
| Date: | 2002 |
| Date Deposited: | 10 Apr 2013 20:27 |
| Last Modified: | 10 Apr 2013 20:27 |
| URI: | https://repository.cshl.edu/id/eprint/28110 |
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