Wais, M., Wu, C., Zahid, T., Sheppy, E., Gillis, J., del Campo, M., Wan, Q., Zhang, L. (2009) Repeated hypoxic episodes induce seizures and alter hippocampal network activities in mice. Neuroscience, 161 (2). pp. 599-613. ISSN 03064522 (ISSN)
Abstract
We examined intra-cranial electroencephalographic activity in a mouse model of global hypoxia in an attempt to explore the pathophysiology underlying hypoxic seizures. Mice between the ages of 22 and 41 days underwent repeated hypoxic challenges, and their behavioral and electroencephalographic activities were monitored continuously before, during and after the challenge. We found that the animals exhibited convulsive behaviors during the hypoxic challenge, but hippocampal/cortical electrographic ictal discharges were recognizable only after the repeated hypoxic challenge. When examined in hippocampal slices in vitro, the post-hypoxic hippocampal circuit was hyper-excitable and had a higher propensity than the control to generate repetitive excitatory field potentials. We postulate that an ictogenic process develops after an initial hypoxic challenge rendering an increase of seizure susceptibility to recurrent hypoxic insults. © 2009 IBRO.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | anoxia electroencephalography epilepsy ischemia rhythm sharp waves animal experiment animal model article controlled study electric potential electroencephalogram hippocampus hypoxia in vitro study mouse nonhuman pathophysiology priority journal seizure Animals Electrophysiological Phenomena Mice Mice, Inbred C57BL Nerve Net Neurons Oxygen Seizures |
| Subjects: | Investigative techniques and equipment Investigative techniques and equipment > electrophysiology organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organs, tissues, organelles, cell types and functions > organelles, types and functions > hypoxia organs, tissues, organelles, cell types and functions > organelles, types and functions organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Gillis Lab |
| Depositing User: | Matt Covey |
| Date: | 2009 |
| Date Deposited: | 04 Apr 2013 13:52 |
| Last Modified: | 04 Apr 2013 13:52 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28084 |
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