Ruthazer, E. S., Akerman, C. J., Cline, H. T. (July 2003) Control of axon branch dynamics by correlated activity in vivo. Science, 301 (5629). pp. 66-70. ISSN 0036-8075
Abstract
To determine how patterned visual activity regulates the development of axonal projections, we collected in vivo time-lapse images of retinal axons from albino Xenopus tadpoles in which binocular innervation of the optic tectum was induced. Axons added branch tips with nearly equal probability in all territories, but eliminated them preferentially from territory dominated by the opposite eye. This selective branch elimination was abolished by blockade of N-methyl-D-aspartate receptors. These results describe a correlation-based mechanism by which visual experience directly governs axon branch dynamics that contribute to the development of topographic maps.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | RECEPTOR ANTAGONISTS DISRUPT NMDA RECEPTOR VISUAL-CORTEX SYNAPSE ELIMINATION RETINOTECTAL AXONS RANA-PIPIENS TIME-LAPSE PROJECTION MAP ZEBRAFISH |
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > axon organs, tissues, organelles, cell types and functions > tissues types and functions organism description > animal behavior > vision organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex |
| CSHL Authors: | |
| Communities: | CSHL labs > Cline lab |
| Depositing User: | Matt Covey |
| Date: | July 2003 |
| Date Deposited: | 11 Jun 2013 15:46 |
| Last Modified: | 11 Jun 2013 15:46 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27951 |
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